DoW Amyotrophic Lateral Sclerosis Research Program, Pilot Clinical Trial Award
<p><strong>Summary: </strong>The fiscal year 2026 (FY26) Amyotrophic Lateral Sclerosis Research Program (ALSRP) Pilot Clinical Trial Award (PCTA) supports the rapid implementation of clinical trials with the potential to have a significant impact on the treatment or management of amyotrophic lateral sclerosis (ALS). Projects may range from phase 1 to small-scale phase 2 trials.</p><p><br></p><p>Applications must address one of the following focus areas:</p><p><br></p><p>· <strong>Biomarker-Driven Interventions: </strong>Disease-modifying interventions, with mechanism-specific biomarkers to predict which clinical trial participants are likely to respond, demonstrate target engagement, and effects on the intended biological pathway.</p><p>· <strong>Clinical Care: </strong>Improving aspects of clinical care and symptom management for ALS.</p><p><br></p><p><strong>Distinctive Features: </strong>Funding from this award mechanism must support a clinical trial. The clinical trial should begin no later than 12 months after the award date or 18 months for U.S. Food and Drug Administration (FDA)-regulated studies.</p><p><br></p><p>Projects proposing a therapeutic intervention (drug, biologic, and/or device) must incorporate biomarkers specific to the intervention into the trial design.</p><p><br></p><p>All pre-applications and applications <u>are required</u> to incorporate community collaboration, as described in Section 3.2.2, to optimize research impact.</p><p><br></p><p>Applications must include a detailed Regulatory Strategy plan that outlines the approach for obtaining regulatory approvals, if required, specifically for the funded portion of the study. In addition, applications must provide a separate Transition Plan that describes how the outcomes of the study will be advanced to the next phase of development, beyond the scope of the funded work.</p>
HT942526ALSRPPCTA
Award Ceiling
$5.6M
Closes
Sep 30, 2026
18d left
DoW Amyotrophic Lateral Sclerosis Research Program, Therapeutic Development Award
<p><strong>Summary: </strong>The fiscal year 2026 (FY26) Amyotrophic Lateral Sclerosis Research Program (ALSRP) Therapeutic Development Award (TDA) supports research ranging from preclinical validation of therapeutic leads through U.S. Food and Drug Administration (FDA) Investigational New Drug (IND)-enabling studies. The proposed studies are expected to be empirical in nature and product-driven. Applicants with limited amyotrophic lateral sclerosis (ALS) experience are strongly encouraged to include collaborators with substantial experience in the relevant ALS model systems, endpoints and pathophysiology.</p><p><br></p><p><strong><em>Applications supported by this award must begin with lead compounds in hand and must already demonstrate proof-of-concept efficacy data in at least one appropriate preclinical model system of ALS, including whole-animal and cellular model systems.</em></strong></p><p><br></p><p><strong>Distinctive Features: <em><u>Mechanism-specific</u>, predictive/cohort-selective, target engagement and pharmacodynamic biomarker development, in parallel to the main therapeutic effort, is a critical component of the FY26 ALSRP Therapeutic Development Award</em></strong>. If appropriate mechanism-specific biomarkers are already available or currently in development, how the existing biomarkers will improve trial design, patient selection, and efficiency or interpretation of the proposed ALS therapeutic approach must be apparent in the application. Development of biomarkers for the purposes of diagnosis, prognosis, or measurement of general disease progression without consideration of the therapeutic development process will not be supported.</p><p><br></p><p>Therapeutic candidates which have already been granted an IND are not appropriate for this mechanism.</p>
HT942526ALSRPTDA
Award Ceiling
$12.0M
Closes
Sep 30, 2026
18d left
Division of Chemistry: Disciplinary Research Programs
This solicitation applies to six (of the nine) CHE Disciplinary Research Programs: Chemical Catalysis (CAT); Chemical Measurement and Imaging (CMI); Chemical Mechanism, Function and Properties (CMFP); Chemical Synthesis (SYN); Environmental Chemical Sciences (ECS); and Macromolecular, Supramolecular and Nanochemistry (MSN). All proposals submitted to these six CHE Disciplinary Research Programs (other than the following exceptions) must be submitted through this solicitation, otherwise they will be returned without review. Exceptions: <ul> <li>Faculty Early Career Development Program (CAREER) proposals should be submitted through the CAREER solicitation (<a href="https://www.nsf.gov/funding/pgm_summ.jsp?pims_id=503214">https://www.nsf.gov/funding/pgm_summ.jsp?pims_id=503214</a>) by the CAREER deadline date specified.<br /><br /></li> <li><span class="l-label__pretext">Facilitating Research at Primarily Undergraduate Institutions: Research in Undergraduate Institutions (RUI) and Research Opportunity Awards (ROA)</span> proposals should be submitted through the RUI/ROA solicitation (<a href="https://www.nsf.gov/funding/pgm_summ.jsp?pims_id=5518">https://www.nsf.gov/funding/pgm_summ.jsp?pims_id=5518</a>) during the window for the appropriateCHE Disciplinary Research Program. In addition to the requirements of the RUI program, proposals should follow the guidance in this solicitation.<br /><br /></li> <li>Proposals for Early-concept Grants for Exploratory Research (EAGER), Grants for Rapid Response Research (RAPID), Research Advanced by Interdisciplinary Science and Engineering (RAISE), and conferences can be submitted anytime after consultation with the cognizant NSF Program Officer.<br /><br /></li> <li>Supplemental funding requeststo existing grantscan be submitted anytime after consultation with the cognizant NSF Program Officer.</li> </ul>
22-605
Award Ceiling
$105.0M
Closes
Sep 30, 2026
18d left
Biological Technologies
The Defense Advanced Research Projects Agency (DARPA) Biological Technologies Office (BTO) is soliciting proposals that leverage biological properties and processes to revolutionize our ability to protect the nation’s warfighters. Specifically excluded is research that primarily results in evolutionary improvements to the existing state of practice.
HR001126S0003
Award Ceiling
—
Closes
Sep 30, 2026
18d left
DoW Amyotrophic Lateral Sclerosis Research Program, Therapeutic Idea Award
<p><strong>Summary: </strong>The fiscal year 2026 (FY26) Amyotrophic Lateral Sclerosis Research Program (ALSRP) Therapeutic Idea Award (TIA) supports new, innovative, high-risk, high-gain ideas aimed at amyotrophic lateral sclerosis (ALS) drug or therapy discovery. The studies supported by this award mechanism are expected to be hypothesis-driven and generate preliminary data for future avenues of therapeutic investigation.</p><p><br></p><p><strong>Distinctive Features: </strong>Potential impact and innovation are important features of the TIA. Applications may demonstrate the ability to achieve interpretable results in the absence of preliminary data supporting the hypothesis. While the inclusion of preliminary data is not prohibited, <strong><em>the strength of the application should rely on the approach.</em></strong></p>
HT942526ALSRPTIA
Award Ceiling
$10.1M
Closes
Sep 30, 2026
18d left
DoW Breast Cancer, Transformative Breast Cancer Consortium Award
<p><strong>Summary: </strong>The fiscal year 2026 (FY26) Breast Cancer Research Program (BCRP) Transformative Breast Cancer Consortium Award supports collaborations and ideas that will transform the lives of individuals with, and/or at risk for, breast cancer and will significantly accelerate progress toward ending breast cancer. Applications must propose a synergistic, highly integrated, multidisciplinary and multi-institutional consortium of leading scientists, clinicians and breast cancer consumer advocates that will address a major problem in a way that a single investigator or group could not accomplish. The consortium’s collaborative efforts must make a transformative impact in breast cancer. All applications must address at least one of the FY26 BCRP overarching challenges or provide adequate justification for exception. If the application addresses a different fundamental issue, the application must couple it with at least one of the overarching challenges.</p><p><strong>Distinctive Features: This funding mechanism allows for up to five Principal Investigators (PIs) which includes the Consortium Director and three or four Project Team PIs. Applications must include at least one breast cancer consumer advocate per project team. </strong>Only the Consortium Director will submit a pre-application, but all PIs will need to submit at the full application stage. Be advised, failure to submit all associated (Consortium Director and Project Team PIs) applications by the full application deadline may result in administrative withdrawal.</p>
HT942526BCRPTBCCA
Award Ceiling
$35.0M
Closes
Sep 30, 2026
18d left
FY25 Long Range Broad Agency Announcement (BAA) for Navy and Marine Corps Science and Technology
<p>ONR, ONRG, and MCWL are interested in receiving proposals for Long-Range S&T Projects that offer potential for advancement and improvement of Navy and Marine Corps operations. Readers should note that this is an announcement to declare ONR, ONRG and MCWL’s broad role in competitive funding of meritorious research across a spectrum of science and engineering disciplines.</p><p><br></p><p>All responsible sources from academia, industry and the research community worldwide may submit proposals under this BAA. All businesses, both small and large, are encouraged to submit proposals and compete for funding consideration.</p>
N0001425SB001
Award Ceiling
—
Closes
Sep 30, 2026
18d left
FY 2026 Continuation of Solicitation for the Office of Science Financial Assistance Program
<p><span style="color: windowtext;">The Office of Science (SC) of the Department of Energy (DOE) hereby announces its continuing interest in receiving applications for support of work in the following program areas: Advanced Scientific Computing Research, Basic Energy Sciences, Biological and Environmental Research, Fusion Energy Sciences, High Energy Physics, Nuclear Physics, and Isotope R&D and Production. On September 3, 1992, DOE published in the Federal Register the Office of Energy Research Financial Assistance Program (now called the Office of Science Financial Assistance Program), 10 CFR 605, as a Final Rule, which contained a solicitation for this program. Information about submission of applications, eligibility, limitations, evaluation and selection processes and other policies and procedures are specified in 10 CFR 605.</span></p> <p><span style="color: windowtext;"> </span></p> <p><span style="color: windowtext;">This NOFO is our annual open solicitation that covers all research areas in SC and is open throughout the Fiscal Year. Any research within SC’s Congressionally authorized mission may be proposed under this NOFO.</span></p> <p><span style="color: windowtext;"> </span></p> <p><span style="color: windowtext;">This NOFO will remain open until September 30, 2026, 11:59 PM Eastern Time, or until it is succeeded by another issuance, whichever occurs first. This NOFO succeeds DE-FOA-0003432, which was published September 30, 2024.</span></p>
DE-FOA-0003600
Award Ceiling
$5.0M
Closes
Sep 30, 2026
18d left
DoW Breast Cancer, Breakthrough Award Level 4
<p><strong>Summary: </strong>The fiscal year 2026 (FY26) Breast Cancer Research Program (BCRP) Breakthrough Award mechanism supports promising research with high potential to lead to or make breakthroughs in breast cancer. All applications must address at least one of the FY26 BCRP overarching challenges or provide adequate justification for exception. Applications must address the challenge in a way that can lead to a breakthrough and have major impact. The FY26 Breakthrough Award mechanism contains four different funding levels designed to support major (but not all) stages of research that will lead to clinical application. Each level specifies a distinct research scope. <strong>This program announcement discusses the Breakthrough Award Level 4.</strong></p><p><strong>Distinctive Features:</strong></p><p>· <strong>Clinical trials are required.</strong></p><p>· The research team must include two or more breast cancer consumer advocates.</p><p>· <strong>This funding mechanism allows for a single Principal Investigator (PI), or two partnering PIs referred to as the Initiating PI and the Partnering PI. </strong>For the Partnering PI Option (PPIO), only the Initiating PI will submit a pre-application, but both PIs will need to submit at the full application stage. Be advised, failure to submit all associated (Initiating and Partnering PI) applications by the deadline may result in administrative withdrawal.</p>
HT942526BCRPBTA4
Award Ceiling
$21.0M
Closes
Sep 30, 2026
18d left
Analysis
The Analysis Program supports research in analysis. Areas of current activity include complex, harmonic, and real analysis; dynamical systems and ergodic theory; functional analysis; mathematical physics; operator theory and operator algebras; partial differential equations and calculus of variations. Conferences Proposals to the Analysis Program for conferences or workshops must be submitted through the program solicitation "Conferences and Workshops in the Mathematical Sciences" (link below). Principal Investigators should carefully read the solicitation to obtain important information regarding the substance of proposals for conferences, workshops, and similar activities. To facilitate timely notification of the availability of support, proposals for conferences, workshops, and similar activities should be submitted 8 months in advance of the start date of the proposed event.
PD-20-1281
Award Ceiling
—
Closes
Sep 30, 2026
18d left
DoW, Ovarian Cancer, Ovarian Cancer Academy – Early-Career Investigator Award
<p>Summary: Initially created in FY09, the OCRP Ovarian Cancer Academy (OCA) is a unique, interactive virtual academy providing intensive mentoring, national networking, collaborations, and a peer group for junior faculty. The overarching goal of the OCA is to conduct innovative and impactful ovarian cancer research while developing successful, highly productive ovarian cancer researchers in a collaborative research and career development environment.</p><p><br></p><p>Distinctive Features: The OCA is a virtual career development and research training platform that consists of Early-Career Investigators (ECIs), their Designated Mentors, and an Academy Dean and Assistant Dean. The OCA-ECI Award is not a traditional career development award; the ECI is expected to participate in monthly webinars and annual workshops and to communicate and collaborate with other members of the Academy (other ECIs, Mentors, the Dean and Assistant Dean) as well as with the advocacy community.</p>
HT942526OCRPOCAECI
Award Ceiling
$4.5M
Closes
Oct 1, 2026
19d left
DoW, Ovarian Cancer, Pilot Award
<p>Summary: The Ovarian Cancer Pilot Award supports research that expands or modifies current thinking about and/or approaches in ovarian cancer, exploring innovative concepts or theories in ovarian cancer that could ultimately lead to critical discoveries or major advancements that will drive the field forward.</p><p><br></p><p>Distinctive Features: Innovation is key. Research projects that demonstrate exceptional scientific merit but lack innovation do not meet the intent of the mechanism. Preliminary data are not required but are allowed for this mechanism.</p><p><br></p><p>This mechanism includes a blinded pre-application component. Pre-applications to this funding opportunity will undergo a blinded pre-application screening. While preparing your pre-application, do not include any material that may identify the PI, a collaborator, or the organization of the PI or collaborator.</p>
HT942526OCRPPA
Award Ceiling
$4.5M
Closes
Oct 1, 2026
19d left
DoW, Ovarian Cancer, Ovarian Cancer Clinical Trial Academy – Early-Career Investigator Award
<p>Summary: Created in FY23, the Ovarian Cancer Clinical Trial Academy (OCCTA) supports the next generation of Early-Career Investigators (ECIs) in clinical trial research to produce effective treatments and cures for ovarian cancer. The OCCTA, through its Leadership, provides for professional and leadership development of the ECIs to include skills and competencies needed to execute clinical trials, providing intensive mentoring, national networking, collaborations, and a peer group for junior clinical trialists. The OCCTA will bring together established investigators (the Academy Dean and Assistant Dean), established Career Guides (mentors), and a group of ECIs/Scholars to conduct successful, highly productive clinical trials in ovarian cancer.</p><p><br></p><p>Distinctive Features: Research funded under this FY26 funding opportunity will support translational research and small-scale, early-phase clinical trials in ovarian cancer. Preliminary data are required, however, these data do not necessarily need to be derived from the ovarian cancer research field. The ECI must be within 12 years of their last postdoctoral research position (Ph.D.), clinical fellowship (M.D.), or equivalent at the time of full application submission deadline. The ECI must commit no less than 25% effort to this award and/or OCCTA activities for the first two years. The Designated Mentor must be a clinical trialist with a strong record of mentoring and training early-career investigators.</p>
HT942526OCRPOCCTAECI
Award Ceiling
$4.2M
Closes
Oct 1, 2026
19d left
Advanced Technological Education
With a focus on two-year Institutions of Higher Education (IHEs), the Advanced Technological Education (ATE) program supports the education of technicians for the high-technology fields that drive our nation's economy. The program involves partnerships between academic institutions (grades 7-12, IHEs), industry, and economic development agencies to promote improvement in the education of science and engineering technicians. It is strongly recommended that projects be faculty-led and required that courses and programs are credit-bearing, although materials developed may also be used for incumbent worker education. Materials may also be adapted and implemented as credit-bearing courses. The ATE program supports curriculum development; professional development of college faculty and secondary school teachers; career pathway development for both students and incumbent workers; and other activities including applied research projects that advance the knowledge base related to technician education. The ATE program encourages partnerships with other entities that may impact technician education. For example, with <ul> <li>the National Institute of Standards and Technology (NIST) Manufacturing Extension Partnerships (MEPs) (<a href="http://www.nist.gov/mep/index.cfm">http://www.nist.gov/mep/index.cfm</a>) as applicable to support technician education programs and the industries they serve; and</li> <li>Manufacturing USA Institutes(<a href="https://manufacturing.gov/">https://manufacturing.gov/</a>) addressing workforce development issues.</li> </ul> The ATE program encourages proposals from <a href="https://www2.ed.gov/about/offices/list/ocr/edlite-minorityinst.html">Minority Serving Institutions</a>as well as other institutions that support the recruitment, retention, and completion (certificate, degree, program)of the full spectrum of diverse talent that society has to offer, which includes underrepresented and underserved communities, in STEM technician education programs that award associate degrees.
24-584
Award Ceiling
$7.5M
Closes
Oct 1, 2026
19d left
EDU Core Research
The EDU Core Research (ECR) program offers this ECR:Core solicitation and invites proposals for fundamental research (curiosity-driven basic research and use-inspired basic research) that contributes to the general, explanatory knowledge that underlies STEM education in one or more of the three broadly conceived Research Areas: Research onSTEM Learning and Learning Environments, Research on Broadening Participation in STEM fields, andResearch on STEM Workforce Development. Within this framework, the ECR program supports a wide range of fundamental STEM education research activities, aimed at learners of all groups and ages in formal and informal settings. Fundamental researchgenerates knowledge and understanding with the potential for broad relevance. The potential implications of ECR fundamental research for improving STEM education practice may be indirect and long-term rather than direct and immediate. Moreover, whether they include basic or use-inspired basic research, all successful ECR:Core proposals focus on the advancement or refinement of foundational knowledge for STEM education. The amount of funding and duration requested in proposals submitted to the ECR:Core solicitation should align with the maturity of the proposed work and the size and scope of the empirical effort. The solicitation has three levels of funding with a range of budget sizes, and proposals may request a duration of 3 to 5 years for any level: (1)Level I proposals may request up to $500,000; (2)Level II proposals may request up to $1,500,000; (3)Level III proposalsmay request up to $2,500,000. All proposals should justify the level of funding and duration in the project description.
21-588
Award Ceiling
$2.5M
Closes
Oct 1, 2026
19d left
DoW Ovarian Cancer, Clinical Trial Award
<p>Summary: The OCRP Clinical Trial Award supports the rapid implementation of clinical trials with the potential to have a significant impact on the treatment or management of ovarian cancer.</p><p><br></p><p>Distinctive Features: Clinical trials may be designed to evaluate promising new products, pharmacologic agents (drugs or biologics), devices, clinical guidance and/or emerging approaches and technologies. Proposed projects may range from small proof-of-concept trials (e.g., pilot, first-in-human, phase 0) to demonstrate the feasibility or inform the design of more advanced trials through large-scale trials to determine efficacy in relevant patient populations.</p>
HT942526OCRPCTA
Award Ceiling
$5.6M
Closes
Oct 1, 2026
19d left
DoW, Ovarian Cancer, Investigator-Initiated Research Award
<p>Summary: The Ovarian Cancer Research Program (OCRP) Investigator-Initiated Research Award is intended to support high-impact research that addresses a critical need and has the potential to make an important contribution to ovarian cancer or patient/survivor care.</p><p><br></p><p>Distinctive Features: Application must contain strong research plan with sound scientific rational and logical reasoning. Preliminary data are required. Research projects may focus on any phase of research, from basic laboratory research through translational research, excluding clinical trials.</p><p><br></p><p>Partnering Principal Investigator (PI) Option: The Partnering PI Option is structured so that two investigators, each of whom will be designated as a PI, will work synergistically on a single project. The results of this partnering project should significantly advance the research beyond what would be possible through individual efforts.</p>
HT942526OCRPIIRA
Award Ceiling
$16.4M
Closes
Oct 1, 2026
19d left
Precision Inertial Navigation & Positioning On an Integrated Tesseract (PINPOINT)
The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals in the following technical area: physics and nonlinear control of inertial measurement units (IMUs) appropriate for tactical and unmanned missions. The Precision Inertial Navigation & Positioning On an Integrated Tesseract (PINPOINT) program will challenge the research community to overcome the decade-long performance plateau of micro-electro-mechanical systems (MEMS) IMUs by exploring revolutionary sensor architectures that operate in highly nonlinear regimes. DARPA is soliciting proposals for the research and development of novel inertial sensors based on physics such as, but not limited to, electromagnetically levitated proof masses, non-linear resonators, and high-velocity tethered microsystems. A central theme of this program is the tight co-design of the physical sensor package with advanced, real-time adaptive control systems necessary to stabilize and harness these complex dynamics. Performers should investigate innovative approaches that enable revolutionary advances in science, devices, or systems. Specifically excluded is research that primarily results in evolutionary improvements to the existing state of practice.
HR001126S0016
Award Ceiling
—
Closes
Oct 2, 2026
20d left
DoW, Peer Reviewed Cancer, Impact Award
<p>Summary: The fiscal year 2026 (FY26) Peer Reviewed Cancer Research Program (PRCRP) Impact Award supports mature research that will have a near-term impact on clinical cancer care in one of the congressionally directed FY26 PRCRP Topic Areas. Applicants must consider how the research project will lead to the advancement of knowledge in cancer research, patient care and/or treatment options in the Military Health System (MHS).</p><p><br></p><p>Distinctive Features:</p><p>• Applications must include preliminary data to support feasibility of the study.</p><p>• Projects must have strong potential to result in a near-term impact in cancer.</p><p>• The funding mechanism allows clinical trials.</p><p>• This funding mechanism allows for a single Principal Investigator (PI), or two partnering PIs referred to as the Initiating PI and the Partnering PI. Only the Initiating PI will submit a pre-application, but both PIs will need to submit full applications. The Partnering PI’s application is an abbreviated package specific to their distinct portion of the research project. Be advised, both applications for a research project may be withdrawn if the initiating or partnering application is rejected or administratively withdrawn.</p>
HT942526PRCRPIPA
Award Ceiling
$45.0M
Closes
Oct 5, 2026
23d left
American Alligators as Ecological Indicators of Everglades Restoration
<p>1) Note: A full study proposal and proposed budget are NOT requested at this time.</p><p><br></p><p>2) Project Title: American Alligators as Ecological Indicators of Everglades Restoration.</p><p><br></p><p>3) Brief Description of Anticipated Work: See Attached SOO for more information.</p><p><br></p><p>4) Period of Performance: Base period: 12 months from date of award. Follow-on (FO) periods: 4 12-month FO periods.</p><p><br></p><p>5) Please send responses or direct questions to:</p><p><br></p><p>Nicholas Aprea</p><p>Grants Specialist</p><p>USACE, Fort Worth District</p><p>Email: nicholas.a.aprea@usace.army.mil</p><p><br></p><p>Kathy Mitchell</p><p>Project Manager</p><p>USACE, Fort Worth District</p><p>Email: kathy.s.mitchell@usace.army.mil</p><p><br></p><p>6) Timeline for Review of Statements of Interest: 30 calendar days from date posted.</p>
W9126G262SOI9558
Award Ceiling
$1.5M
Closes
Oct 5, 2026
23d left